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anford Burnham Prebys Medical Discovery Institute
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# Query Length Result vs. Range Score %id Covered by template(s)
1 gi|6319249|ref|NP_009332.1|(removed signalp:1-20) hypothetical protein; Pau8p (YAL068C) [Saccharomyces cerevisiae] 100 COG0516 13-99 -6.620 14  [S] COG3309 Uncharacterized virulence-associated protein D
2 gi|33438754|ref|NP_878038.1| Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Yal067w-ap (YAL067W-A) [Saccharomyces cerevisiae] 75 COG0516 3-75 -7.160 14  [R] KOG1533 Predicted GTPase
3 gi|6319250|ref|NP_009333.1| Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide; Seo1p (YAL067C) [Saccharomyces cerevisiae] 593 COG0516 57-585 -74.000 13  [G] KOG2533 Permease of the major facilitator superfamily
4 gi|6319252|ref|NP_009335.1| Putative protein of unknown function; has homology to FLO1; possible pseudogene; (YAL065C) [Saccharomyces cerevisiae] 128 COG0516 79-128 -7.120 26  [T] KOG3797 Peripheral-type benzodiazepine receptor and related proteins
5 gi|6319253|ref|NP_009336.1| Fungal-specific protein of unknown function; Yal064w-bp (YAL064W-B) [Saccharomyces cerevisiae] 126 COG0516 1-114 -7.190 10  [I] KOG3750 Inositol phospholipid synthesis protein, Scs3p
6 gi|7839146|ref|NP_058136.1| Putative protein of unknown function; YAL064C-A is not an essential gene; Yal064c-ap (YAL064C-A) [Saccharomyces cerevisiae] 126 COG0516 6-110 -7.590 [S] COG4719 Uncharacterized protein conserved in bacteria
7 gi|6319254|ref|NP_009337.1| Protein of unknown function; may interact with ribosomes, based on co-purification experiments; (YAL064W) [Saccharomyces cerevisiae] 108 COG0516 1-81 -7.320 22  [S] COG4642 Uncharacterized protein conserved in bacteria
8 gi|33438755|ref|NP_878039.1| Putative protein of unknown function; identified by expression profiling and mass spectrometry; Yal063c-ap (YAL063C-A) [Saccharomyces cerevisiae] 96 COG0516 16-96 -5.600 19  [K] COG5414 TATA-binding protein-associated factor
9 gi|6319255|ref|NP_009338.1|(removed signalp:1-24) Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation; Flo9p (YAL063C) [Saccharomyces cerevisiae] (Range: 1-500) 500 COG0516 144-500 -11.900 [R] KOG3253 Predicted alpha/beta hydrolase
182-500 -19.400 10  [S] KOG4502 Predicted membrane protein
199-487 -22.300 [R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)
10 gi|6319255|ref|NP_009338.1|(removed signalp:1-24) Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation; Flo9p (YAL063C) [Saccharomyces cerevisiae] (Range: 251-750) 500 COG0516 1-478 -15.200 [TU] KOG3895 Synaptic vesicle protein Synapsin
14-316 -21.500 [R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)
11 gi|6319255|ref|NP_009338.1|(removed signalp:1-24) Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation; Flo9p (YAL063C) [Saccharomyces cerevisiae] (Range: 501-1000) 500 COG0516 1-298 -22.100 [R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)
1-500 -16.300 10  [TU] KOG3895 Synaptic vesicle protein Synapsin
12 gi|6319255|ref|NP_009338.1|(removed signalp:1-24) Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation; Flo9p (YAL063C) [Saccharomyces cerevisiae] (Range: 751-1250) 500 COG0516 1-467 -16.500 10  [TU] KOG3895 Synaptic vesicle protein Synapsin
197-500 -23.500 [R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)
13 gi|6319255|ref|NP_009338.1|(removed signalp:1-24) Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation; Flo9p (YAL063C) [Saccharomyces cerevisiae] (Range: 1001-1298) 298 COG0516 2-287 -26.100 [R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)
14 gi|6319256|ref|NP_009339.1| NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; Gdh3p (YAL062W) [Saccharomyces cerevisiae] 457 COG0516 3-457 -52.000 24  [E] KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases
31-454 -60.800 28  [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase
15 gi|6319257|ref|NP_009340.1| Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene; Bdh2p (YAL061W) [Saccharomyces cerevisiae] 417 COG0516 1-382 -78.200 29  [Q] KOG0024 Sorbitol dehydrogenase
16 gi|6319258|ref|NP_009341.1| NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source; Bdh1p (YAL060W) [Saccharomyces cerevisiae] 382 COG0516 2-380 -79.500 26  [Q] KOG0024 Sorbitol dehydrogenase
17 gi|6319259|ref|NP_009342.1| Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export; Ecm1p (YAL059W) [Saccharomyces cerevisiae] 212 COG0516 3-154 -6.290 11  [R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains
18 gi|6319260|ref|NP_009343.1|(removed signalp:1-19) Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast; Cne1p (YAL058W) [Saccharomyces cerevisiae] 483 COG0516 1-482 -111.000 27  [O] KOG0675 Calnexin
19 gi|41629666|ref|NP_009345.2| Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p; Gpb2p (YAL056W) [Saccharomyces cerevisiae] 880 COG0516 4-765 -28.300 [TR] KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes
156-870 -54.000 [T] KOG2437 Muskelin
265-874 -57.500 11  [R] KOG0379 Kelch repeat-containing proteins
20 gi|6319263|ref|NP_009346.1| Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation; Pex22p (YAL055W) [Saccharomyces cerevisiae] 180 COG0516 5-131 -7.140 [S] COG5353 Uncharacterized protein conserved in bacteria


FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Li W, Pio F, Pawlowski K, Godzik A. Saturated BLAST: an automated multiple intermediate sequence search used to detect distant homology. Bioinformatics. 2000 Dec;16(12):1105-10.