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Query: TM0013 TM0013 281894 Purified-2001-08-24, from JCSG0516

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFENEILFDNGQHKFMFLGWEEKEEEIVQTNQYLILDGNEGILLDPGGAHVFPRVMSNVAEVVDLSSIRHIFYTHQDPDVTSGILLWLSICENAKIYISSLWVRFLPHFGIYDQKRIVPISDKGTKIKLLSGNELEILPAHFLHSTGNFVLYDPVAKILFSGDIGAAVFEKGKRYRYVDDFERHLPLMEAFHKRYMSSNAACKKWVDMVSKKKIDMIAPQHGAVFRGESVKKFLEWFRNLKCGVDLIDNLYSLLast
1 -25.600sp|Q68D91|MBLC2_HUMAN Metallo-beta-lactamase domain-containing protein 2 OS=Homo sapiens GN=MBLAC2 PE=1 SV=3  ali follow..  15  29............................RANIWLVRGSEQDVVIDTGLG------LRSLPEYLYSSGLLLAVATHVHFDHSGGLYQFDRVAVHHA-VVRTPSPGWRARQFRVQAVQPTLILQDGDVINL-GDRQLTVMHMP--HSRGSICLHDKDRKILFSGDVV--YDGSLIDWLPYSRISDYVGTCE--------------RLIELVDRGLVEKVLPGHFNTFGAERLFRLASNY................ 247
2 -23.900sp|A4D2B0|MBLC1_HUMAN Metallo-beta-lactamase domain-containing protein 1 OS=Homo sapiens GN=MBLAC1 PE=2 SV=1  ali follow..  17  66...........................GGAEAALEEAARGPILVDTGGPWAREALLGALAGQVAPGDVTLVVGTHGHSDHIGNLGLF----PGAALLVSHDFCLPGGRYLPHG-------LGEGQPLRLGPG--LEVWATP--HGGQRDVSVTALGTVVVAGDVFERDGDEDSWQALSEDPAAQERSRKRVLVV-------------------ADVVVPGHGPPFR........................... 236
3 -21.700sp|Q53H82|LACB2_HUMAN Beta-lactamase-like protein 2 OS=Homo sapiens GN=LACTB2 PE=1 SV=2  ali follow..  19  31.............................TNTYLVGTGPRRILIDTGEPAI-PEYISCLKQALTEFAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTP--HTDDHMALLLEEENAIFSGD-----------------------CILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVIHNAKIQQYISHRNIREQQIELVKIIYK. 247
4 -16.000sp|Q6PII5|HAGHL_HUMAN Hydroxyacylglutathione hydrolase-like protein OS=Homo sapiens GN=HAGHL PE=2 SV=1  ali follow..  13  15................................YLVIEELEAVAVDVAVPKRLLEIVGREG------SLTAVLTTHHHWDHARGNPELARLRPGLAVLGADERIFSLTR-----------RLAHGEELRF-GAIHVRCLLTP--HTAGHMSYFCPDPPALFSGDALSVAGCGSCLEGSAQQMYQSLAELGTFAQKVEPCNDHVRAKLSWAKARPLSRRGKRVGGEGTGFGVGGALR.................. 225
5 -15.400sp|Q16775|GLO2_HUMAN Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens GN=HAGH PE=1 SV=2  ali follow..  13  62...............................MYLVIDDEEAAIVDPVQPQKVVDAARKHG------KLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTH-----------KITHLSTLQV-GSLNVKCLATP--HTSGHICYFGSEPPAVFTGDTLGKFYEGTADEMCKA--HEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMR.................. 274
6 -15.200sp|Q8N490|PNKD_HUMAN Probable hydrolase PNKD OS=Homo sapiens GN=PNKD PE=1 SV=2  ali follow..  15  126..........................VLSDNSYLIIDTQLAVAVDPSDPRAVQASIEKEG------TLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQ----------DGIPYLTHPLCHQDVVSV-GRLQIRALATP--HTQGHLVYLYKGPSCLFSGDLLETMLSSLDTVLGLGDDTLLWPGHEYFAGVVEPENLARERKMQWVQRQRLERKGTCPSTLGEERSYNPFLR.................. 344
7 -14.500sp|Q9UKF6|CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens GN=CPSF3 PE=1 SV=1 (Range: 1-300)  ali follow..  10  21.........................QEVGRSCIILEFKGRKIMLDCGIHPGLEGMDAPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKT-KGRTFMTHATKAIYRKVSNISADDMLYTETD-HEVKEVAGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQ----MAAEIPNIKPDILIIESTYGTHIHEKREEREARFCNTVHDI--RGLIPVF-ALGRAQELLLILDEYWQ.............. 258
8 -13.800sp|O95571|ETHE1_HUMAN Protein ETHE1, mitochondrial OS=Homo sapiens GN=ETHE1 PE=1 SV=2  ali follow..  20  30........................EPVSCTFTYLLGDSREAVLIDPV-LETAPRDAQLIKEL----RLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLH-----------IEDGDSIRF-GRFALETRASP--HTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQ------------------GCAKTLYHSVHEKIFTLPGDLIYPAH................................ 195
9 -12.900sp|Q5TA45|INT11_HUMAN Integrator complex subunit 11 OS=Homo sapiens GN=CPSF3L PE=1 SV=2  ali follow..  11  13.........................QDVGRSCILVSIAGKNVMLDCGDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMV-DGPIYMTHPTQAICPILLEDYRKKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMT----GAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHET--KVLIPVFALGRAQELCILLETFWERMNLKVPIY...... 266
10 -12.200sp|Q6IQ20|NAPEP_HUMAN N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D OS=Homo sapiens GN=NAPEPLD PE=1 SV=2  ali follow..  11  130...........................LGHATVMVEMDELIFLTDPIFSS--KRFRRSPCTISELPPIDAVLISHNHYDHLNSVIALNERFGNELRWFVPLGLDWMQKCGCENVIEL----DWWEENCVPGHDKVTFVFTPSQHWCKSWSVLGPWNRFFFAGDT-GYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVEEAVRIHTDVQTKKSMAIHWGTFA........................... 348
11 -12.000sp|Q9BQ52|RNZ2_HUMAN Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens GN=ELAC2 PE=1 SV=2 (Range: 451-750)  ali follow..  14  39..................GSAIPMKIRNVSATLVNISPDTSLLLDCGE-GTFGQLCRHYGDQVDLGTLAAVFVSHLHADHHTGLPSILLQLHPLLVVAPNQLKAWLQQYHNQCQEVLHHISMIPAKCLQEGAEISEFQTCLVRHCKGCALVHTSGWKVVYSGDTLVRMGKDATLLIHEATLEDGLE-----EEAVEKTHSTTSQAISVGMRMNAEFIMLNH................................ 274
12 -11.200sp|P78559|MAP1A_HUMAN Microtubule-associated protein 1A OS=Homo sapiens GN=MAP1A PE=1 SV=6 (Range: 1-300)  ali follow..  18  47............................RGDSALFAVNGFNILVDGGSDRKSCFWKLV-----HLDRIDSVLLTHIGADNLPGINGLLQRKVAELEEEQSQGSSSYSDW................................................................................................................................................ 123
13 -11.000sp|Q9P2I0|CPSF2_HUMAN Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens GN=CPSF2 PE=1 SV=2 (Range: 1-300)  ali follow..  13  14.........................QEESALCYLLQVDEFRFLLDCGWDEHFSDIIDSLRKHVH--QIDAVLLSHPDPLHLGALPYAVGKLGNCAIYATIPVYKMGQMFMYDLYQDKIQQLKFSQIVNLKGKGHLSITPLPAGHMIGGTIWKDGEEEIVYAVDFNHK-HLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLET--NVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLAL.. 268
14 -10.500sp|Q66K74|MAP1S_HUMAN Microtubule-associated protein 1S OS=Homo sapiens GN=MAP1S PE=1 SV=2 (Range: 151-450)  ali follow..  100............................LGDAAFFAVNGFTVLVNGGSNP--SSFWKLVRHL---DRVDAVLVTHPGADSLPGLNSLLRRKLAERSESWDDRLRRLISFNACEAASRLARGEDEAELALSLLAQLGITPLPLSRGPVPAKPTVLFEKMGVGR----DMYVLHPPSAGAERTLASVCALLVWHP---------AGPGEKVVRVLFPGCTPPACLLDGLVRLQH..................... 300
15 -9.860sp|P46821|MAP1B_HUMAN Microtubule-associated protein 1B OS=Homo sapiens GN=MAP1B PE=1 SV=2 (Range: 151-450)  ali follow..  13  119............................RGDSALFAVNGFNMLINGGSER--KSCFWKLIRHLD--RVDSILLTHIGDDNLPGINSMLQRKIAELEEEQSQGSTTNSDWMKNLISPDLGVV--------------------FLNVPENLKNPEPNIKMKRSIEEACFTLQYLN--------KLSMKPEPLFRSVGNTIDPVILFQKMGVGKLEMYVLNPVKS----SKEMQYFMQQWTG.............. 293
16 -9.710sp|Q9H816|DCR1B_HUMAN 5` exonuclease Apollo OS=Homo sapiens GN=DCLRE1B PE=1 SV=1  ali follow..  19  1.............................MNGVLI--PHTPIAVD---------------SLRRAGTARLFFLSHMHSDHTVGLSS------ARPLYCSPITAHLLHRHLQVSKQWIQALEGESHVLPLQETMTVTLLDAN--HCPGSMFLFEYFGTILYTGDF------------------------RYTPSMLKEPALTLGKQIHTL--LDNTNCNPALVLPSRQEAAHQIVQLIRKHPQHNIKIG-LYSL 184
17 -9.310sp|Q9BQ52|RNZ2_HUMAN Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens GN=ELAC2 PE=1 SV=2 (Range: 1-300)  ali follow..  10  65.......................AGSRDSGAALYVFSEFNRYLFNCGE----GVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLPKCVLSGPPQLEKYLEIFSGPLKGIELAVRPHSAPEYEDETMTVYQIPIHSEQRRGKHQPWQSPERPL-RSSDSESNENEPHLPHGVSQRRGVRDSSLVVAFICKLHLKRGNFLVLKAKEMGLAAIAPIIAAVKDGKSI....................... 284
18 -9.290sp|Q6PJP8|DCR1A_HUMAN DNA cross-link repair 1A protein OS=Homo sapiens GN=DCLRE1A PE=1 SV=3 (Range: 601-900)  ali follow..  15  111.....................................................GFTVDAFQYGVVEGCTAYFLTHFHSDHYAGLSK------TFPVYCSEITGNLLKNKLHVQEQYIHPLP---DTECIVNGVKVVLLDAN--HCPGAVMILPNGTVILHTGDF---------------------------ADPSMERSLLADQKVHML--LDTTYCSPEYTFPSQQEVIRFAINTAFEAVT-ALVVCGTYSI 281

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan;71(1):112-22. Epub 2006 Oct 17.