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anford Burnham Prebys Medical Discovery Institute
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Query: 4exs_B mol:protein length:272 Beta-lactamase NDM-1, from PDB0516

Results of FFAS03 search in PDB0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLRLVLast
1 -107.0004exs_B mol:protein length:272 Beta-lactamase NDM-1  ali model  100  1MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLRLV 272
2 -102.0003rkk_A mol:protein length:237 Beta-lactamase NDM-1  ali model follow..  97  1.................................SNANYMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR.. 237
3 -101.0005a5z_A mol:protein length:251 BETA-LACTAMASE NDM-1  ali model follow..  99  1...........................MGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLRL. 244
4 -100.0004gyq_A mol:protein length:243 Beta-lactamase NDM-1  ali model follow..  98  1...........................SNAIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGAADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR.. 243
5 -100.0004tyf_A mol:protein length:231 NDM-4  ali model follow..  99  3.........................................GDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR.. 231
6 -100.0004rl2_A mol:protein length:246 Beta-lactamase NDM-1  ali model follow..  98  1........................GSHMGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR.. 246
7 -99.6003spu_A mol:protein length:265 Beta-lactamase NDM-1  ali model follow..  99  1..........................MPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLRKL 246
8 -91.7001a7t_A mol:protein length:232 METALLO-BETA-LACTAMASE  ali model follow..  28  1......................................AQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIPNHWHGDCIGGLGYLQRKGVQSYANQMTIDLAKEKG--------LPVPEHGFTDSLTVSLDGLQCYYLGGGHATDNIVVWLPTENILFGGCMLKDNQTTSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGNYGGTELIEHTKQIVNQYIE. 227
9 -91.6001znb_A mol:protein length:232 METALLO-BETA-LACTAMASE  ali model follow..  29  1......................................AQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTETLVNWVADSLHAKVTTFIPNHWHGDCIGGLGYLQKKGVQSYANQMTIDLAKEKG--------LPVPEHGFTDSLTVSLDGLQCYYLGGGHATDNIVVWLPTENILFGGCMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVNQYIE. 227
10 -90.5002y87_A mol:protein length:265 METALLO-B-LACTAMASE  ali model follow..  30  1......MFQIRSFLVGISAFVMAVLGSAAYSAQPGGEYPTVDDIPVGEVRLYKIGDGVWSHIATQK-LGDTVYSSNGLIVRDADELLLIDTAWGAKNTVALLAEIEKQIGLPVTRSISTHFHDDRVGGVDVLRAAGVATYTSPLTRQLAEAAGNEVPAHS----LKALSSSGDVVRFGPVEVFYPGAAHSGDNLVVYVPAVRVLFGGCAVHEASRESAGNVADANLAEWPATIKRIQQRYPEAEVVIPGHGLPGGLELLQHTTNVVKTHKV. 260
11 -90.0004uwo_B mol:protein length:266 METALLO-BETA-LACTAMASE VIM-26  ali model follow..  32  1.....MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSF-DGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHS----LEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKN. 261
12 -89.8002yz3_A mol:protein length:266 Metallo-beta-lactamase  ali model follow..  32  1.....MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSF-DGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEG----NEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTN. 261
13 -89.6005a87_A mol:protein length:248 METALLO-BETA-LACTAMASE VIM-5  ali model follow..  32  1.......................GPSPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSF-DGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRKAGVATYASPSTRRLAEAEG----NEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLALSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVTAHKN. 243
14 -89.5002uyx_A mol:protein length:228 BETA-LACTAMASE II  ali model follow..  29  1................................ASQKVEKTVIKNETGTISISQLNKNVWVHTELGS-FNGEAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHASRIGGIKTLKERGIKAHSTALTAELAKKNGYE--------EPLGDLQTVTNLKFGNVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEVGDKGLLLHTLDLLK..... 228
15 -88.6002nze_A mol:protein length:222 Beta-lactamase II  ali model follow..  30  1......................................KTVIKNETGTISISQLNKNVWVHTELGS-FNGEAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHADHIGGIKTLKERGIKAHSTALTAELAKKNGYE--------EPLGDLQTVTNLKFGNVETFYPGKGHTEDNIVVWLPQYNILVGGSLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEVGDKGLLLHTLDLLK..... 222
16 -88.1003l6n_A mol:protein length:219 metallo-beta-lactamase  ali model follow..  24  1...........................................QVKDFVIEPPIKNNLHIYKTFGVF-GGKEYSANSMYLVTKKGVVLFDVPWEKVQYQSLMDTIKKRHNLPVVAVFATHSHDDRAGDLSFFNNKGIKTYATAKTNEFLKKDGKA--------TSTEIIKTGKPYRIGGFVVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSNSATDLGYIKEANVEQWPKTINKLKAKYSKATLIIPGHDEWKGGGHVEHTLELLNK.... 218
17 -88.0003fcz_A mol:protein length:222 Beta-lactamase 2  ali model follow..  31  1......................................KTVIKNETGTISISQLNKNVWVHTELGSFNGEA-VPSSGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDAIITHAHADRIGGIKTLKERGIKAHSTALTAELAKKNGYE--------EPLGDLQTVTNLKFGNVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVSKRYRNINAVVPSHGEVGDKGLLLHTLDLLK..... 222
18 -87.9001m2x_A mol:protein length:223 class B carbapenemase BlaB-1  ali model follow..  25  1...............................................DVKIEKLKDNLYVYTTYNTFNGTK-YAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKP--------RAQYTFDNNKSFKVGKFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEYQQ. 217
19 -86.1004wd6_A mol:protein length:233 Metallo-beta-lactamase  ali model follow..  29  1..........................................NDEVPELRIEKVKENIFLHTSYSRVNGFGLVSSNGLVVIDKGNAFIVDTPWSDRDTETLVHWIRK-NGYELLGSVSTHWHEDRTAGIKWLNDQSISTYATTSTNHLLKENKKE---------PAKYTLKGNESTLVDIEVFYPGGGHTIDNVVVWLPKSKILFGGCFVRSLDSEGLGYTGEAHIDQWSRSAQNALSRYSEAQIVIPGHGKIGDIALLKHTKSLAETASN. 221
20 -85.0002ynt_B mol:protein length:233 GIM-1 PROTEIN  ali model follow..  29  1..........................................SQGHKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQAYIIDTPWSEEDTKLLLSWATD-RGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTKKLLAREGKP--------VPTHYFKDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSHEWEALGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESASN. 221
21 -84.7005acp_A mol:protein length:250 GIM-1 PROTEIN  ali model follow..  27  1............MKNVLVFLILLVALPALAQG-------------HKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQAYIIDTPWSEEDTKLLLSWATD-RGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTKKLLAREGKP--------VPTHYFKDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSHEREGLGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESASN. 238
22 -84.1004ubq_A mol:protein length:229 Beta-lactamase  ali model follow..  32  1.........................................AGARLPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVE-RGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSF---------SGVSYWLVKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLG---DANLEAWPKSAKILMSKYVKAKLVVSSHSEIGDASLLKRTWEQAVKGLN. 219
23 -83.3004f6h_A mol:protein length:236 Beta-lactamase  ali model follow..  31  1..........................................AESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVE-RGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSF---------SGVNYWLVKIEVFYPGPGHTPDNVVVWLPERKILFGGGFIKPYGLGNLG---DANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLN. 218
24 -81.7003q6v_A mol:protein length:233 Beta-lactamase  ali model follow..  17  2............................................SEKNLTLTHFKGPLYIVED------KEYVQENSMVYIGTDGITIIGATWTPETAETLYKEIRKVSPLPINEVINTNYHTDRAGGNAYWKTLGAKIVATQMTYDLQKSQWGSKYPNLEKSLPDTVFPGDFNLQNGSIRAMYLGEAHTKDGIFVYFPAERVLYGNCILKEN----LGNMSFANRTEYPKTLEKLKGLIEKVDSIIAGHDTPHDVGLIDHYLTLLEKAPK. 233
25 -81.2001x8h_A mol:protein length:228 Beta-lactamase  ali model follow..  21  1..............................................AGMSLTQVSGPVYVV------EDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVADLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGGCILKEK----LGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPHGPELIDHYEALIKAAPQ. 226
26 -79.1004bp0_A mol:protein length:250 METALLO-B-LACTAMASE  ali model follow..  22  1...................................GPKSSDHVDLPYNLTATKIDSDVFVVT------DRDFYSSNVLVAKMLDGVVIVSSPFENLGTQTLMDWVAKTMKPKKVVAINTHFHLDGTGGNEIYKKMGAETWSSDLTKQLRLEENKKDRSHPVPADNVFDLKQGKVFSFSNVEVSFPGPAHSPDNVVVYFPKKKLLFGGCMIKPKELGYLG---DANVKAWPDSARRLKKF--DAKIVIPGHGEWGGPEMVNKTIKVAEKAVG. 246
27 -34.2003lvz_A mol:protein length:294 Blr6230 protein  ali model follow..  13  1...........MRRLTAALCALTLLSTGAQAQTIKDFLAVAMKKWTAPFEPFQLIDNIYYV---------GTDGIAVYVIKTSQGLILMDTA-MPQSTGMIKDNIAKLKVADIKLILNTHAHLDHTGGFAEIKKEGAQLVAGERDKPLLEGGYYPGDEAFPAVKVDRAVKEGDRVTLGDTTLAHATPGHSPGCTSWEMTVKDVLFFCSGTVALNRLVGQPTYAGIVDDYRATFAKAKAM--KIDVLLGPHPEVYG................. 247
28 -33.9004p62_A mol:protein length:295 Metallo-beta-lactamase AIM-1  ali model follow..  15  1......MKRRFTL--LGSVVALALSSTALASDAPASRGCADDAGWNDPAMPQKVYGNTWYV---------GTCGISALLVTSDAGHILVDAA-TPQAGPQILANIRALRPEDVRAIVLSHEHFDHAGSLAELQKAGAPVYARAPAIDTLKRGLPDRTDPQFPVANIVTLADDGVVSVGPLALAVASPGHTPGGTSWTWRDCRQMVYADSLTAISDDVYRYSDDGYLAAFRNTLARVAAL--DCDILVTPHPSASG................. 255
29 -33.7004awy_B mol:protein length:303 METALLO-BETA-LACTAMASE AIM-1  ali model follow..  15  1......MKRRFTL--LGSVVALALSSTALASDAPASRGCADDAGWNDPAMPLKVYGNTWYV---------GTCGISALLVTSDAGHILVDAA-TPQAGPQILANIRALRPEDVRAIVFSHEHFDHAGSLAELQKAGAPVYARAPAIDTLKRGLPDRTDPQFPVANIVTLADDGVVSVGPLALAVASPGHTPGGTSWTWRDCRQMVYADSLTAISDDVFRYSDDGYLAAFRNTLARVAAL--DCDILVTPHPSASG................. 255
30 -33.6001sml_A mol:protein length:269 PROTEIN (PENICILLINASE)  ali model follow..  17  1............................AEVPLPQLRAYTVDASWLQPMAPLQIADHTWQI---------GTEDLTALLVQTPDGAVLLDGG-MPQMASHLLDNMKARTPRDLRLILLSHAHADHAGPVAELKRRGAKVAANAESAVLLARGGSDDLHTYPPANADRIVMDGEVITVGGIVFAHFMAGHTPGSTAWTWTDTRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRAL--PCDVLLTPHPGASNWDYAAGARAGAK..... 242
31 -33.5002zwr_A mol:protein length:207 Metallo-beta-lactamase superfamily protein  ali model follow..  18  9......................................................................GPLQENAYLVETGEGPVLIDPGDE---PEKLLALFQTT-GLIPLAILLTHAHFDHVGAVAPLVEADLPVYLHPLDLPLYEGADLAARAIPKPPLPVRPLEEGMRL---GFQVLHL-PGHSPGHVAFYDPEGAQVFSGDLLFRGSVGRY-DLPGADPKALFASLKRLLSL-PPETRVHPGHGPGTTLGLEARTNPFLTGLE.. 204
32 -33.0002p97_A mol:protein length:201 Hypothetical protein  ali model follow..  12  6.....................................................HRPDLYSWSTFNPARN---IDFNGFAWIRPEGNILIDPV---ALSNHDWKHLESLGG--VVWIVLTN--SDHVRSAKEIADQYTKIAGPVAEKENFPIY------------CDRWLSDGDELVPG-LKVMELQGSKTPGELALLLEE-TTLITGDLVRAYRAGGLEILPDEKLMNKQKVVASVRRLLEKVEAVLVGDGWSVFRDGRDRLKELVATL... 200
33 -32.3002q0j_A mol:protein length:321 Quinolone signal response protein  ali model follow..  17  5.................................................SSGLVPRGSHMLR-DDDLCLLGDVQVPVFLLRGEASWALVEGGISRD-AELVWADLCRADPSQVHYWLITHKHYDHCGLLPYLCPRNVQVLASERTCQAWKSESAVRVVERLNRLPVRAVADGEWLELGPLQVIE-AHGHSDDHVVFYDVRRRRLFCGDALFDEAEGVWRPLVFDDMEAYLESLERLQRL-PTLLQLIPGHGGLLRGRLAADGAE........ 249
34 -32.3003vpe_A mol:protein length:262 Metallo-beta-lactamase  ali model follow..  16  6.............................................SSPQQPFTIYGNTHYV---------GTGGISAVLLSSPQGHILVDGT-TEKGAQVVAANIRAMKLSDVKYILSTHSHEDHAGGISAMQKLGATVLAGAANVDTLRTGVSPKSDPQFGSAKVRAVADGELVKLGPLAVAHATPGHTEGGITWTWQSCEVVFADSLTAVSADSYRFSDHPEVVASLRGSFEAVEKL--SCDIAIAAHPEVND................. 220
35 -31.9001jt1_A mol:protein length:263 FEZ-1, class B3 metallo-beta-lactamase  ali model follow..  12  1.........................................AYPMPNPFPPFRIAGNLYYV---------GTDDLASYLIVTPRGNILINSDLEAN-VPMIKASIKKLKFSDTKILLISHAHFDHAAGSELIKQQKAKYMVMDEDVSVILSGGKSDFHYFTQSTVDKVLHDGERVELGGTVLAHLTPGHTRGCTTWTMKLKDAVIIGSIGVNPGYKLVDNITPKIAEDYKHSIKVLESM--RCDIFLGSHAGMFD................. 220
36 -31.7002zo4_A mol:protein length:317 Metallo-beta-lactamase family protein  ali model follow..  14  1..................................................MKALLPGLYLLPVPIPYP-------NLYLLQGAGEVALVDTALGTRAARGALELHLAELGQDVKTILLTHHHPDHYGLSGFFEGLGARVFLHEGALQGIRETVEKTRERVHPPQNPLPLRDGEALEVAGKRLVLWTPGHADGHAAFYLEEEGVLLAGDALLEKVSPNVGLWAENPLKDFLRSLDRLADL--GARVAYAGHFGP--EELKAHHQARLEALLAL 261
37 -31.3005aeb_A mol:protein length:272 LRA-12  ali model follow..  17  2.............................MASQKVKEPTVSNADWSKPYRPFRIAGNLYYI---------GTYDLACYLITTKQGNIIVNTGLAAS-ALQIKNNIKALKLTDTKILLTTQAHYDHLGAMAEIKKIGAKLMADEGDATVMADGGSSDYSMFEPIIADRLLHDKDTIQLGDTKLMLHHPGHTKGSCSFLFDTKDILIANMPIVIEKKFSEVSSYPGIAKDYAYTLQAMKNL--SFDIWVASHASQFS................. 232
38 -31.0005iqk_A mol:protein length:271 beta-lactamase Rm3  ali model follow..  13  1...................................TPGCEVCATWNADQAPFRLFGNTYYV---------GMKGLSSVLVTSPQGHVLIDGG-LPESAPKIIANIGALRIEDVKLILNSHGHIDHAGGLAELQRRNALVAASPSAALDLASGEVGPDDPQYPVKDMRLARDGGQFNVGPVYLAHATPGHTPGGLSWTWQSCDGPRCLNMVYADSINAVSRPGPNALADLRHSFETLEKL--PCDVLISAHPEASQ................. 228
39 -29.2003adr_A mol:protein length:261 Putative uncharacterized protein ST1585  ali model follow..  13  20..........................................................................ATVYVMCGEKLTVMIDAGVSNSIADFSFL-------DKLDYIVLTHLHIDHIGLLPELLQVKAKVLVKSGFKKYLTSEDGLKLEKKLDQDKVIEVEGNEEFDLGGYRMLIYTPGHARHHMSVLV--DDFLFTGDSAGAYFNGVVIPTPVIDYKMYMESLKRQIELKP--KVVGFAHGGLVSPKIMEEHLKQMLSKEEI 229
40 -27.9001ztc_A mol:protein length:221 hypothetical protein TM0894  ali model follow..  12  29..........................................................................STVVYLEHKDRRIIIDPGNLSS-MDELEEKFSELGISPITDVLFTHVHLDHIFNSVLFENATFYVHEVYKTKNYLSFGGRIYSKVISSWKNVVLLKGEESLFDEKVKVFHT-PWHAREHLSFLLDTENVLITGDITPNRL-----SYYDIIKGYGSVQVKNFLDRVGRIDLLVFPHDAP................... 208
41 -27.0004v0h_A mol:protein length:266 METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROT  ali model follow..  14  14....................VPGDPYSVVVLLQGYAEPEGVGDAVRADGSVTLVLPQTRGPASSHRESPRGSGGAEAALEEAARGPILVDTGGPWAR-EALLGALAGVAPGDVTLVVGTHGHSDHIGNLGLFPGAALLVSHDFCLPGGRYLPHGLGEGQPLRLGP-------------GLEVWAT-PGHGGQRDVSVVVAGTVVVAGDVFERDGDEDSWQALSEDPAAQERSRKRVLVV---ADVVVPGHGPP................... 234
42 -25.4004ad9_A mol:protein length:289 BETA-LACTAMASE-LIKE PROTEIN 2  ali model follow..  17  8.................................................RVERLSNRVVRVLG-CNPGPMTLQGTNTYLVGTGPRRILIDTGEIPEYISCLKQALTEF-NTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYT-PGHTDDHMALLLEEENAIFSGDCILGEGTTVF-----EDLYDYMNSLKELLKI--KADIIYPGHGPV-----IHNAEAKIQQY... 214
43 -24.7002xf4_A mol:protein length:210 HYDROXYACYLGLUTATHIONE HYDROLASE  ali model follow..  11  11........................................................................FSQNCSLIWCEQLAALVDPGGD---AEKIKQEVDAS-GVTLMQILLTHGHLDHVGAASELAQHGVPVIGPEKEDEFWLQGLPAQSRECQPLTPDRWLNDGDRVSVGNVTLVLHCPGHTPGHVVFFDEQSQLLISGDVIFKGGVGRS-DFPRGDHTQLIDAIKRKLLPLGDDVTFIPGHGPLSTLGYERLHNPFLQ..... 209
44 -24.6005i0p_A mol:protein length:366 Beta-lactamase domain protein  ali model follow..  13  1...........................MAMNALEHQLDYPFADTLPAAGDTFEVAPGVRWLRMPLPFS-------NLWLL-GQAGWTIVDCGISSEAIRTHWEQIRHLDGLPVLRVLVTHCHPDHFGLANWLCEGNVRLWMTPAALDKLRSRRSYYSDLVPAVPPRYRLREGDAVKIGART-VVTGYGHSPEHCALHSEADGVLISGDMVLPRISTNVSVFDLEPLALYLESLGRYETM-APDTLVLPSHGKP--AQLRAHHDARLEEVRVA 299
45 -24.2002r2d_A mol:protein length:276 Zn-dependent hydrolases  ali model follow..  10  41........................................................................IPVSAYLIQCTDATVLYDTGCHPESECNLPERLRQLGLSPISTVVLSHLHNDHAGCVEYFGKSRLIAHEDEFATAVRYFATGDHSSPYIVKDIEAWLATPRNWDLPGVNLLNFGTGHASGMLGLAVRLEKFLLVSDACYTATNYGPPARRAGDTIGYDRTVSHIRQYAESRSLVLFGHDREQFASLIKSTDGFYE..... 276
46 -23.8001qh3_A mol:protein length:260 PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE)  ali model follow..  16  9........................................................................LTDNYMYLVIDDEAAIVD----PVQPQKVVDAARKH-GVKLTTVLTTHHHWDHAGGNEKLVKLGLKVYGGDDRIGAL----------------THKITHLSTLQVGSLNVKCLAPCHTSGHICYFVSEPPAVFTGDTLFVAGC---GKFYEGTADEMCKALLEVLGRLPPDTRVYCGH---------EYTINNLKFARHV 186
47 -23.5003dha_A mol:protein length:254 N-Acyl Homoserine Lactone Hydrolase  ali model follow..  13  1....................................GRISMTVKKLYFIPAGRCMLDHSSVNSALTPGKLLNLPVWCYLLETEEGPILVDTGMPESAVDRIVNILKRVGYEPLLYIISSHLHFDHAGGNGAFT--NTPIIVQRTEYEAALHREEYMKECILPHLNYKIIEGDYEV-VPGVQLLYT-PGHSPGHQSLFIETEQVLLTIDASYEDEVPFAGF----DPELALSSIKRLKEVVKKEKIIFFGH-DIEQEKSCRVFPEYI...... 254
48 -23.3001xm8_A mol:protein length:254 glyoxalase II  ali model follow..  20  9........................................................................LKDNYAYILHDEDVGVVDPS----EAEPIIDSLKRS-GRNLTYILNTHHHYDHTGGNLELKDRGAKVIGSAMDKDRIPGIDMALKDG-----------DKWMFAGHEVHVMDT-PGHTKGHISLYFPGSRAIFTGDTMFSLSC---GKLFEGTPKQMLASLQKITSL-PDDTSIYCGH---------EYTLSNSKFALSL 182
49 -23.2002br6_A mol:protein length:252 AIIA-LIKE PROTEIN  ali model follow..  12  2.......................................DMTVKKLYFIPAGRCMLDHSSVNSALTPGKLLNLPVWCYLLETEEGPILVDTGMPESAVDRIVNILKRVGYEPLLYIISSHLHFDHAGGNGAFT--NTPIIVQRTEYEAALHREEYMKECILPHLNYKIIEGDYEV-VPGVQLLYT-PGHSPGHQSLFIKTEQVLLTIDASYKENFEDEVPFAGFDPELALSSIKRLKEVVKKEKIIFFGH-DIEQEKSCRVFPEYI...... 252
50 -22.4004fek_A mol:protein length:262 Putative diflavin flavoprotein A 5  ali model follow..  11  2.........................................SDSKPRDVQVLPIATNTKVLRAEIEYALERGTTSNS-YVIEGDKTAIIDPPVESFMKIYLEALQQTVNLKKLDYVILGHFSPNRIPTFKALLELQITFVCSLPAAGDLRAAFPDDNLNI------LPMRGKETLDLGKLKFLPIPSPRWPAGLCTYDVQTQILYTDKIFKEDQRYYFNCLMAPHAIHVEAALEKISDL--QVRLYAVGHGPLVRTSLIALTQAYADWSK.. 251
51 -22.0003aj3_A mol:protein length:274 4-pyridoxolactonase  ali model follow..  13  2..............................................SDTKVYLLDGGSLVLDGYHVFWNRGRFPVYSILIEHAEGRFLIDTGYDYEKHQTIPGALGLLGLEPIDVVVNSHFHFDHCGGNKYFPHAKKICHRSEAEAAEARGATAQLLEGTTRANSTFEGIDGDVDLARGVKLIST-PGHSIGHYSLLVEFPRILFTIDAAYTQKSTLCQAAFHIDPVAGVNSMRKVKKLAEDHGALMYSHDMDNFKTYRTGTQFY....... 267
52 -21.0002p18_A mol:protein length:311 Glyoxalase II  ali model follow..  15  31........................................................................LKDNFSYLINDHTLAAVDVNAD---YKPILTYIEEHLKQTFSTILSTHKHWDHSGGNAKLKAELEAMNSTVPVVVV--------GANDSIPAVTKPVREGDRVQVGDLSVEVIDPCHTRGHVLYKVQHPQALFTGDTMFIAGI---GAFFEGDEKDMCRAMEKVYHIHDKVTFIFPGH---------EYTSGFMTFSEKT 233
53 -20.3004le6_A mol:protein length:324 Organophosphorus hydrolase  ali model follow..  14  1......MRLFSLSTALSSAMIALVSLPLQAAAPAQQKTQVPGRMALGDFEVTALYDGYLLARMFVASEKGVQTAVNAYLINTGDNLVLIDTGAAQCFGPVVQTNLKASGYQPVDTVLLTHLHPDHACGL-EVPQAEAEFWLDEATMAKAPEGMQGMFKMAQQAVAPYAKMNKLKPYKTEGELLVASPGHTPGHTSYLFKSQSLLVWGDILLNHAVPEVVFEFDVDSDQARQSRQRILAEAATDKLWVPGLGHV................... 303
54 -20.3004o98_A mol:protein length:337 organophosphorus hydrolase  ali model follow..  14  1......MRLFSLSTALSSAMIALVSLPLQAAAPAQQKTQVPGRMALGDFEVTALYDGYLLARMFVASEKGVQTAVNAYLINTGDNLVLIDTGAAQCFGPVVQTNLKASGYQPVDTVLLTHLHPDHACGLVEVPQAEAEFWLDEATMAKAPEGMQGMFKMARQAVAPYAKMNKLKPYKTEGELLVASSGHTPGHTSYLFKSQSLLVWGDILINHAVPEVVWEFDVDSDQARQSRQRILAEAATDKLWVPGLGHV................... 303
55 -20.2004chl_A mol:protein length:238 PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL  ali model follow..  16  28.................................................................................ESREAVLIDP----ETAPRDAQLIKEL-GLRLLYAVNTHCHADHITGSGLLRSLGCQSVISRLSGAQA----------------DLHIEDGDSIRFGRFALETRAPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTL-PGDCLIYPAHDRTLNPRLTLSCEEFVKIMGNL 213
56 -19.6003esh_A mol:protein length:280 Protein similar to metal-dependent hydrolase  ali model follow..  27.....................................................VPKPLWSKQYNANERNQINLPTHPILIQTAQYNLIIDAGIGNGKESHIIADLANLTPKDIDYVLMTHMHFDHAAGLTDQAGHNAIHVVQQDEWHEFIAPNIRS-KSTYWDKNKGDYSNKLILFEKHFEPMQHSGGHSFGHTIITIESDKAVHMGDIFPTTAHKNPLWVTAYDDYPMQSIREKIPYFIQQQYWFLFYHDENYFAVKYSDDGENIDAYILR 273
57 -19.4001p9e_A mol:protein length:331 Methyl Parathion Hydrolase  ali model follow..  16  1MPLKNRLLARLSCVAAVVAATAAVAPLTLVSTAHAAAPQVRTSAPGGDFEITALSDGTQSALAKSFQKAPLETSVTGYLVNTGSKLVLVDTGAAGLFGPRLAANLKAAGYQPVDEIYITHMHPDHVGGLDFWLSQTNLDKAPDDESKGFFKGAMASLNPYVKAGKFKPFSGNTDLVPGIKALASHG--HTPGHTTYVVESQKLALLGDLILVAAVPSVTTQLDSDSKSVAVERKKAFADAAKGGYLIPGIGHI................... 311
58 -19.3004xuk_A mol:protein length:291 Putative hydrolase  ali model follow..  15  13...............................................DVQITALLDGTILKKYYADQEKGVQTSINAFLVNIGKSLILIDSGAASCFGSSVLSNLKASGYQPVDTILLTHLHPDHVCGISYVSNDEASFWLDPKQAAKLPKEKQANYLGTVEKIKQAIYQAKQRFKTYKLGDDIQGAGHTPGHFSYELKTESIVFIGDIVHSHTVPETAIEYDIDPKKAVETRLKQFANFAKNGQTIPGIGHTYSAD............... 278
59 -18.9002ohh_A mol:protein length:404 Type A flavoprotein fprA  ali model follow..  13  2...............................................KAAAKRISDGVY-WTGVLDWD--QGTTYNAYLVCGDEGVALIDNGTFDELMARVEDALQQVGMERVDYIIQNHVEKDHSGVLVELHRREAPIYCTEVAVKGLLKHYPSLREAEFMTVKT---GDVLDLGGKTLTFLETPLLHWPDSMFTLLDEDGILFSNDAFGQHLCCPQRLDREIPEYILLKKFDEVKELLERIQMIAPSHGQI................... 236
60 -18.7004ysb_A mol:protein length:233 Metallo-beta-lactamase family protein  ali model follow..  18  22.................................................................................ATRQAVLIDP----EQVDRDLQMVAEL-DLTLTHVFDTHVHADHITASGALRERQATVVGSVNGASCA----------------NVQVRHGDEVRVGQLVFQVL-PGHTDDSISYLLGDR--VFTGDALLVRGNGRTDFQNGNASQLYDSLTRVLFTL-PDETLVYPGHD..................... 171
61 -18.4002gcu_A mol:protein length:245 Putative hydroxyacylglutathione hydrolase 3  ali model follow..  16  27..................................................................................DKPALLIDP----KTVDRDLKLIDEL-GLKLIYAMNTHVHADHVTGTGLLKTKGVKSVISKASGSKA----------------DLFLEPGDKVSIGDIYLEVRAPGHTAGCVTYVTPQPRMAFTGDAVLIRGCGRTDFQEGSSDQLYESVHSQIFTL-PKDTLIYPAHDMQHNPRLTKDKETFKTIMSNL 217
62 -18.2001e5d_A mol:protein length:402 RUBREDOXIN:OXYGEN OXIDOREDUCTASE  ali model follow..  10  1................................................MQATKIIDGFHDFHGYTLSPMGTTYNA---YLVEDEKTTLFDTVKAEYKGELLCGIASVIDPKKIDYLVIQHLELDHAGALPALIEAPEKIFTSSLGQKAMESHFHYKDWPV------QVVKHGETLSLGKRTVTFYET-HWPDSMVSWFADEKVLISNDIFGQNIAASERFSDQIPVHTLLKAIETLVGAGVAPEFICPDHGVI................... 229
63 -18.1002q9u_A mol:protein length:414 A-type flavoprotein  ali model follow..  10  8................................................VQDQEMIPGVY-VRIFHGYHTDEGSSYNS-YFIDDECPTVIDSVKYPFAEEWLSRIAACCPLDKIKYVVMNHAEGDHASSLKDHYHKNATFVCTKKCQEHLKILYGMEKATW------LIVDDKYTLKIGKRTLKFIPV-HWPDSTFTYCPEDKILFSNDGFGQHYATSRRWADECDVSHVRKALEVASTV--EIKYILSAHGVSWRGDAMGLAIAEYDRWSK. 251
64 -18.0004zo2_A mol:protein length:294 Acylhomoserine lactonase  ali model follow..  16  13...............................................ELELFILTDGYIILKDNFRADHYIDMAINILLVKTKEKLILMDTGMGIERTGFLLKSLQKAGFSAITDIFLSHAHPDHIGGV-FISKIEHDFWINASIKDFNNSALKAHPERLNQIIPALQIQPKLKFYDLNKTLYQLAPGHTPGLTVTTISSEKLMYVADLIHSDVIPDWGFSGDTDLDIATASRKKFLKQLADTKARAPGLGFT................... 278
65 -17.8004d02_A mol:protein length:479 ANAEROBIC NITRIC OXIDE REDUCTASE FLAVORUBREDO  ali model follow..  12  3...................................................IVVKNNIH-WVGQRDYKTLRGSSYNS-YLIREEKNVLIDTVDHKFSREFVQNLRNEIDLADIDYIVINHAEEDHAGALTELMAQDTPIYCTANAIDSINGPEWNF----------NVVKTGDTLDIGNLIFVETPMLHWPDSMMTYLTGDAVLFSNDAFGQHYCDEHLFNDEVDQTELTPKITEILGFNLPVDMIATSHGVVWRDNPTQIVELYLKWAA.. 243
66 -17.7001ycf_A mol:protein length:398 Nitric oxide reductase  ali model follow..  10  2.................................................QPVAITDGIY-WVGAVDFSTHRGTTYNAYLIV-DDKTALVDTVYEPFKEELIAKLKQIKDPVKLDYLVVNHTESDHAGAFPAIMELDAHVLCTQRAFDSLKAHYSHIDFNY------TIVKTGTSVSLGKRSLTFIEA-HWPDSMFTYVPEEALLLPNDAFGQHIATSVRFDDQVDAGLITKKLDEIQKINLAIKTIAPSHGIIWRKDPGRIIEAYARWAE.. 247
67 -17.2003r2u_A mol:protein length:466 Metallo-beta-lactamase family protein  ali model follow..  15  30..........................................................................SQASYLIGCQKAMIID----PIRDLSSYIRVADEEGLTITHAAETHIHADFASGIRDVAIKNANIY--------VSGESDDTLGYKNMPNHTHFVQHNDDIYVGNIKLKVL-PGHTPESISFLLTDEGGLFSGDFIFVGKAVKVEGSSEIGAKQMFKSIESIKDL-PDYIQIWPGHGSPCGKSLGAIPTSTLGYEKQT 237
68 -17.0003tp9_A mol:protein length:474 BETA-LACTAMASE and RHODANESE DOMAIN PROTEIN  ali model follow..  14  15..........................................................................AHASYLVGCQEACVID----PARDVEPYLLTAKREGLRIVAALETHIHADFVSGAREMADRGAAICVSD-------EGPPEWKSEYVKAYPHRLLKDGDELHFGNVRIVVM-PGHTPEHVSYLLYDGKALFSGDFVFVGRVAGESGSSEALARQMFRSLRKFEAL-PDHVQVLPAHGSACGKALGAVPSSTVGYEKL. 222
69 -16.6001vme_A mol:protein length:410 Flavoprotein  ali model follow..  11  12................................................TERIFDDPEIYIRYFEAVWEIPEGISYNAYLVKLNGANVLIDG-WKGNYAKEFIDALSKIVDKEITHIIVNHTEPDHSGSLPATLKTDVEIIASNFGKRLLEG---------YGIKDVTVVKDGEEREIGGKKFKFVMT-HWPDTMVTYL--DGILFSCDVGGYLLPEILDDSNESVVERYLEGAEKLSSL--KIKALLPGHGLIWKKDPQRLLNHYVSVAK.. 254
70 -14.8002qed_A mol:protein length:258 Hydroxyacylglutathione hydrolase  ali model follow..  17  16........................................................................FQDNYIWVLTNDECVIVDPG----EAAPVLKAIAEH-KWMPEAIFLT----DHVGGVKELLQHQMTVYG---------------PAETQDKGATHLVGDGDTIRVLGEKFTLFAPGHTLGHVCYFSRP--YLFCGDTLFSGGC---GRLFEGTPSQMYQSLMKINSL-PDDTLICCAH---------EYTLANIKFALSI 181
71 -14.7004nur_A mol:protein length:633 PSdsA  ali model follow..  12  89..................................................LFEVTDGIYQVRNYD--------LSNMTIVEGKDGITIFDPLISQETAKAALDLYYKHRKKPVVAVIYTHSHVDHYGGVRGVVDEAVKIYAPLGFLEHAVAENTTSAGTVTLIPPTDIIKETHVIDGLTYEFMYAPGSEAPAEMLYYIKEKKALNAAEDSTHTNTYSLRGAKIRDPLAWSKYLNEALKLWGDDVQVMPVWGNKEVREQLSLQRDMYRYIND. 352
72 -14.6003kl7_A mol:protein length:235 Putative metal-dependent hydrolase  ali model follow..  14  29........................................................................IKHGSLMLTYDNHSIQVDPVSEYADYTTF---------PKADIILITHEHGDHLDAIQAVEKSDTEIIANENSQKKLGKGKVLKNGDTDTSISYMKIEAVPAYNTTPGRDKYHPRHRDNG-YILTFDGLRVYIAGDTEDIPEMKDLKDVNQPYTMTVSQAAKAARMFSP--KILYPYHYGDTKIGELKDALK........ 217
73 -14.5002cfu_A mol:protein length:658 SDSA1  ali model follow..  13  107..................................................LFEVAEGIYQVRGFD--------LANITFIRGDSGWIVVDTLTTPATARAAYELVSRELERPIRTVIYSHAHADHFGGVRGLVEPQVQIIAPAGFMEAAIKENGLARGPLSLLAPTRLIEEDLVLDGVPFTFQNTPGTESPAEMNIWLPRQKALLMAENVVGTNLYTLRGAEVRDALGWSKYINQALHRFGRQAEVMPRWGNAEIVEVLEKQRDLYGYLHD. 370
74 -14.5004pdx_A mol:protein length:640 Putative alkyl/aryl-sulfatase YjcS  ali model follow..  12  89..................................................LFKVTDKMYQVRGQD--------ISNITFVEGEKGIIVIDPLVTPPAAKAALDLYFQHRQKPIVAVIYTHSHTDHYGGVKGIISEAVQVIAPAGFMDEAISENTLATGDPSIIAPTKTIVEKMIIDGLEFDFLMTPGSEAPAEMHFYIPALKALCTAENATHTNFYTLRGAKTRDTSKWTEYLNETLDMWGNDAEVLPVWGNKHINDYIGKYRDTIKYIHD. 352
75 -14.2002az4_A mol:protein length:429 hypothetical protein EF2904  ali model follow..  10  14....................................................................GILTIGGTVIEVAYKDAHIFFDFGTETLINNRLVPELKDLYDPRLGYVFLSHAHLDHS-RMINYLDPAVPLYTLKETKMILNSLNRSPFEEKNFTREMIGLNKNDVIKVGEISVEIVPVDHDAYGLLIRTPDHFITYTGDLRLHGHNRE-------ETLAFCEKAKHTELLMMEGVSIFPEREPDPAQIAVVSEEDLVQHLVRL 247

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Jaroszewski L, Li W, Godzik A. In search for more accurate alignments in the twilight zone. Protein Sci. 2002 Jul;11(7):1702-13.