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anford Burnham Prebys Medical Discovery Institute
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Query: 4gyq_A mol:protein length:243 Beta-lactamase NDM-1, from PDB0516

Results of FFAS03 search in PDB0516
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst SNAIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGAADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLRLast
1 -105.0004gyq_A mol:protein length:243 Beta-lactamase NDM-1  ali model  100  1SNAIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGAADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 243
2 -104.0003rkk_A mol:protein length:237 Beta-lactamase NDM-1  ali model follow..  97  1......SNANYMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 237
3 -104.0004rl2_A mol:protein length:246 Beta-lactamase NDM-1  ali model follow..  98  4MGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 246
4 -103.0005a5z_A mol:protein length:251 BETA-LACTAMASE NDM-1  ali model follow..  98  2.GEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 243
5 -102.0004tyf_A mol:protein length:231 NDM-4  ali model follow..  99  3..............GDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 231
6 -102.0003spu_A mol:protein length:265 Beta-lactamase NDM-1  ali model follow..  98  2PGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 244
7 -100.0004exs_B mol:protein length:272 Beta-lactamase NDM-1  ali model follow..  98  28PGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 270
8 -93.5001a7t_A mol:protein length:232 METALLO-BETA-LACTAMASE  ali model follow..  28  1...........AQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIPNHWHGDCIGGLGYLQRKGVQSYANQMTIDLAKEKG--------LPVPEHGFTDSLTVSLDGLQCYYLGGGHATDNIVVWLPTENILFGGCMLKDNQTTSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGNYGGTELIEHTKQIVNQYI 226
9 -93.4001znb_A mol:protein length:232 METALLO-BETA-LACTAMASE  ali model follow..  28  1...........AQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTETLVNWVADSLHAKVTTFIPNHWHGDCIGGLGYLQKKGVQSYANQMTIDLAKEKG--------LPVPEHGFTDSLTVSLDGLQCYYLGGGHATDNIVVWLPTENILFGGCMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVNQYI 226
10 -92.1005a87_A mol:protein length:248 METALLO-BETA-LACTAMASE VIM-5  ali model follow..  33  5LAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDG-AVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRKAGVATYASPSTRRLAEAEG----NEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLALSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVTAHK 242
11 -91.3002uyx_A mol:protein length:228 BETA-LACTAMASE II  ali model follow..  28  1.....ASQKVEKTVIKNETGTISISQLNKNVWVHTELGSFNGEA-VPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHASRIGGIKTLKERGIKAHSTALTAELAKKNGYE--------EPLGDLQTVTNLKFGNVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEVGDKGLLLHTLDLLK... 228
12 -90.4002nze_A mol:protein length:222 Beta-lactamase II  ali model follow..  30  1...........KTVIKNETGTISISQLNKNVWVHTELGSFNG-EAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHADHIGGIKTLKERGIKAHSTALTAELAKKNGYE--------EPLGDLQTVTNLKFGNVETFYPGKGHTEDNIVVWLPQYNILVGGSLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEVGDKGLLLHTLDLLK... 222
13 -90.3003fcz_A mol:protein length:222 Beta-lactamase 2  ali model follow..  30  1...........KTVIKNETGTISISQLNKNVWVHTELGSFNGEA-VPSSGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDAIITHAHADRIGGIKTLKERGIKAHSTALTAELAKKNGYE--------EPLGDLQTVTNLKFGNVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVSKRYRNINAVVPSHGEVGDKGLLLHTLDLLK... 222
14 -89.9003l6n_A mol:protein length:219 metallo-beta-lactamase  ali model follow..  24  1................QVKDFVIEPPIKNNLHIYKTFGVFGGKE-YSANSMYLVTKKGVVLFDVPWEKVQYQSLMDTIKKRHNLPVVAVFATHSHDDRAGDLSFFNNKGIKTYATAKTNEFLKKDGKA--------TSTEIIKTGKPYRIGGFVVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSNSATDLGYIKEANVEQWPKTINKLKAKYSKATLIIPGHDEWKGGGHVEHTLELLNK.. 218
15 -89.6001m2x_A mol:protein length:223 class B carbapenemase BlaB-1  ali model follow..  25  1....................DVKIEKLKDNLYVYTTYNTFNGTK-YAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKP--------RAQYTFDNNKSFKVGKFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEYQ 216
16 -89.3002y87_A mol:protein length:265 METALLO-B-LACTAMASE  ali model follow..  31  22AAYSAQPGGEYPTVDDIPVGEVRLYKIGDGVWSHIATQKLGDTV-YSSNGLIVRDADELLLIDTAWGAKNTVALLAEIEKQIGLPVTRSISTHFHDDRVGGVDVLRAAGVATYTSPLTRQLAEAAGNEVPAHS----LKALSSSGDVVRFGPVEVFYPGAAHSGDNLVVYVPAVRVLFGGCAVHEASRESAGNVADANLAEWPATIKRIQQRYPEAEVVIPGHGLPGGLELLQHTTNVVKTHK 259
17 -89.1002yz3_A mol:protein length:266 Metallo-beta-lactamase  ali model follow..  34  23LAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDG-AVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEG----NEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHT 260
18 -89.0004uwo_B mol:protein length:266 METALLO-BETA-LACTAMASE VIM-26  ali model follow..  34  23LAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDG-AVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHS----LEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHK 260
19 -87.8004wd6_A mol:protein length:233 Metallo-beta-lactamase  ali model follow..  30  1...............NDEVPELRIEKVKENIFLHTSYSRVNGFGLVSSNGLVVIDKGNAFIVDTPWSDRDTETLVHWIRK-NGYELLGSVSTHWHEDRTAGIKWLNDQSISTYATTSTNHLLKENKKE---------PAKYTLKGNESTLVDIEVFYPGGGHTIDNVVVWLPKSKILFGGCFVRSLDSEGLGYTGEAHIDQWSRSAQNALSRYSEAQIVIPGHGKIGDIALLKHTKSLAETAS 220
20 -86.6005acp_A mol:protein length:250 GIM-1 PROTEIN  ali model follow..  27  4.VLVFLILLVALPALAQGHKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQAYIIDTPWSEEDTKLLLSWATD-RGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTKKLLAREGKP--------VPTHYFKDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSHEREGLGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESAS 237
21 -86.5002ynt_B mol:protein length:233 GIM-1 PROTEIN  ali model follow..  29  1...............SQGHKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQAYIIDTPWSEEDTKLLLSWATD-RGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTKKLLAREGKP--------VPTHYFKDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSHEWEALGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESAS 220
22 -85.7004ubq_A mol:protein length:229 Beta-lactamase  ali model follow..  32  1..............AGARLPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVE-RGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSF---------SGVSYWLVKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLG---DANLEAWPKSAKILMSKYVKAKLVVSSHSEIGDASLLKRTWEQAVKGL 218
23 -84.9004f6h_A mol:protein length:236 Beta-lactamase  ali model follow..  31  1...............AESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVE-RGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSF---------SGVNYWLVKIEVFYPGPGHTPDNVVVWLPERKILFGGGFIKPYGLGNLG---DANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGL 217
24 -84.7001x8h_A mol:protein length:228 Beta-lactamase  ali model follow..  21  1...................AGMSLTQVSGPVYVV------EDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGGCILKEK----LGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPHGPELIDHYEALIKAAP 225
25 -83.7003q6v_A mol:protein length:233 Beta-lactamase  ali model follow..  17  2.................SEKNLTLTHFKGPLYIVED------KEYVQENSMVYIGTDGITIIGATWTPETAETLYKEIRKVSPLPINEVINTNYHTDRAGGNAYWKTLGAKIVATQMTYDLQKSQWGSKYPNLEKSLPDTVFPGDFNLQNGSIRAMYLGEAHTKDGIFVYFPAERVLYGNCILKEN----LGNMSFANRTEYPKTLEKLKGLIEKVDSIIAGHDTPHDVGLIDHYLTLLEKAP 232
26 -80.7004bp0_A mol:protein length:250 METALLO-B-LACTAMASE  ali model follow..  21  2.........PKSSDHVDLPYNLTATKIDSDVFVVT------DRDFYSSNVLVAKMLDGVVIVSSPFENLGTQTLMDWVAKTMKPKKVVAINTHFHLDGTGGNEIYKKMGAETWSSDLTKQLRLEENKKDRSHPVPADNVFDLKQGKVFSFSNVEVSFPGPAHSPDNVVVYFPKKKLLFGGCMIKPKELGYLG---DANVKAWPDSARRLKKF--DAKIVIPGHGEWGGPEMVNKTIKVAEKAV 245
27 -34.6002zwr_A mol:protein length:207 Metallo-beta-lactamase superfamily protein  ali model follow..  18  9...........................................GPLQENAYLVETGEGPVLIDPGDE---PEKLLALFQT-TGLIPLAILLTHAHFDHVGAVAPLVEADLPVYLHPLDLPLYEGADLAARAIPKPPLPVRPLEEGMRL---GFQVLHL-PGHSPGHVAFYDPEGAQVFSGDLLFRGSVGRY-DLPGADPKALFASLKRLLSL-PPETRVHPGHGPGTTLGLEARTNPFLTGLE 204
28 -34.4001sml_A mol:protein length:269 PROTEIN (PENICILLINASE)  ali model follow..  16  1.AEVPLPQLRAYTVDASWLQPMAPLQIADHTWQI---------GTEDLTALLVQTPDGAVLLDGG-MPQMASHLLDNMKARTPRDLRLILLSHAHADHAGPVAELKRRGAKVAANAESAVLLARGGSDDLHTYPPANADRIVMDGEVITVGGIVFAHFMAGHTPGSTAWTWTDTRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRAL--PCDVLLTPHPGASNWDYAAGARAGAK... 242
29 -34.2002p97_A mol:protein length:201 Hypothetical protein  ali model follow..  11  6..........................HRPDLYSWSTFNPARN---IDFNGFAWIRPEGNILIDPV---ALSNHDWKHLESLGG--VVWIVLTN--SDHVRSAKEIADQYTKIAGPVAEKENFPIY------------CDRWLSDGDELVPG-LKVMELQGSKTPGELALLLEE-TTLITGDLVRAYRAGGLEILPDEKLMNKQKVVASVRRLLEKVEAVLVGDGWSVFRDGRDRLKELVATL. 200
30 -33.9002q0j_A mol:protein length:321 Quinolone signal response protein  ali model follow..  16  5......................SSGLVPRGSHMLR-DDDLCLLGDVQVPVFLLRGEASWALVEGGISRD-AELVWADLCRADPSQVHYWLITHKHYDHCGLLPYLCPRNVQVLASERTCQAWKSESAVRVVERLNRLPVRAVADGEWLELGPRHRLQVAHGHSDDHVVFYDVRRRRLFCGDALFDEAEGVWRPLVFDDMEAYLESLERLQRL-PTLLQLIPGHGGLLRGRLAADGAE...... 249
31 -33.3003vpe_A mol:protein length:262 Metallo-beta-lactamase  ali model follow..  16  6..................SSPQQPFTIYGNTHYV---------GTGGISAVLLSSPQGHILVDGT-TEKGAQVVAANIRAMKLSDVKYILSTHSHEDHAGGISAMQKLGATVLAGAANVDTLRTGVSPKSDPQFGSAKVRAVADGELVKLGPLAVAHATPGHTEGGITWTWQSCEVVFADSLTAVSADSYRFSDHPEVVASLRGSFEAVEKL--SCDIAIAAHPEVND............... 220
32 -33.0003lvz_A mol:protein length:294 Blr6230 protein  ali model follow..  14  17GAQAQTIKDFLAVAMKKWTAPFEPFQLIDNIYYV---------GTDGIAVYVIKTSQGLILMDTA-MPQSTGMIKDNIAKLKVADIKLILNTHAHLDHTGGFAEIKKEGAQLVAGERDKPLLEGGYYPGDEAFPAVKVDRAVKEGDRVTLGDTTLAHATPGHSPGCTSWEMTVKDVLFFCSGTVALNRLVGQPTYAGIVDDYRATFAKAKAM--KIDVLLGPHPEVYG............... 247
33 -32.8001jt1_A mol:protein length:263 FEZ-1, class B3 metallo-beta-lactamase  ali model follow..  12  1..............AYPMPNPFPPFRIAGNLYYV---------GTDDLASYLIVTPRGNILINSDLEAN-VPMIKASIKKLKFSDTKILLISHAHFDHAAGSELIKQQKAKYMVMDEDVSVILSGGKSDFHYFTQSTVDKVLHDGERVELGGTVLAHLTPGHTRGCTTWTMKLKDAVIIGSIGVNPGYKLVDNITPKIAEDYKHSIKVLESM--RCDIFLGSHAGMFD............... 220
34 -32.3002zo4_A mol:protein length:317 Metallo-beta-lactamase family protein  ali model follow..  14  1.......................MKALLPGLYLLPVPIPYP-------NLYLLQGAGEVALVDTALGTRAARGALELHLAELGQDVKTILLTHHHPDHYGLSGFFEGLGARVFLHEGALQGIRETVEKTRERVHPPQNPLPLRDGEALEVAGKRLVLWTPGHADGHAAFYLEEEGVLLAGDALLEKVSPNVGLWAENPLKDFLRSLDRLADL--GARVAYAGHFGP--EELKAHHQARLEALL 259
35 -32.2004p62_A mol:protein length:295 Metallo-beta-lactamase AIM-1  ali model follow..  16  20ALASDAPASRGCADDAGWNDPAMPQKVYGNTWYV---------GTCGISALLVTSDAGHILVDAA-TPQAGPQILANIRALRPEDVRAIVLSHEHFDHAGSLAELQKAGAPVYARAPAIDTLKRGLPDRTDPQFPVANIVTLADDGVVSVGPLALAVASPGHTPGGTSWTWRDCRQMVYADSLTAISDDVYRYSDDGYLAAFRNTLARVAAL--DCDILVTPHPSASG............... 255
36 -32.2004awy_B mol:protein length:303 METALLO-BETA-LACTAMASE AIM-1  ali model follow..  16  20ALASDAPASRGCADDAGWNDPAMPLKVYGNTWYV---------GTCGISALLVTSDAGHILVDAA-TPQAGPQILANIRALRPEDVRAIVFSHEHFDHAGSLAELQKAGAPVYARAPAIDTLKRGLPDRTDPQFPVANIVTLADDGVVSVGPLALAVASPGHTPGGTSWTWRDCRQMVYADSLTAISDDVFRYSDDGYLAAFRNTLARVAAL--DCDILVTPHPSASG............... 255
37 -32.0005aeb_A mol:protein length:272 LRA-12  ali model follow..  15  2..MASQKVKEPTVSNADWSKPYRPFRIAGNLYYI---------GTYDLACYLITTKQGNIIVNTGLAAS-ALQIKNNIKALKLTDTKILLTTQAHYDHLGAMAEIKKIGAKLMADEGDATVMADGGSSDYSMFEPIIADRLLHDKDTIQLGDTKLMLHHPGHTKGSCSFLFDTKDEQRSYRILIANMPTIV-SSYPGIAKDYAYTLQAMKNL--SFDIWVASHASQFS............... 232
38 -31.9005iqk_A mol:protein length:271 beta-lactamase Rm3  ali model follow..  13  11..................NADQAPFRLFGNTYYV---------GMKGLSSVLVTSPQGHVLIDGG-LPESAPKIIANIGALRIEDVKLILNSHGHIDHAGGLAELQRRNALVAASPSAALDLASGEVGPDDPQYPVKDMRLARDGGQFNVGPVYLAHATPGHTPGGLSWTWQSCDGPRCLNMVYADSINAVSRPGPNALADLRHSFETLEKL--PCDVLISAHPEASQ............... 228
39 -30.2003adr_A mol:protein length:261 Putative uncharacterized protein ST1585  ali model follow..  13  20...............................................ATVYVMCGEKLTVMIDAGVSNSIADFSFL-------DKLDYIVLTHLHIDHIGLLPELLQVKAKVLVKSGFKKYLTSEDGLKLEKKLDQDKVIEVEGNEEFDLGGYRMLIYTPGHARHHMSVLV--DDFLFTGDSAGAYFNGVVIPTPVIDYKMYMESLKRQIELKP--KVVGFAHGGLVSPKIMEEHLKQMLS.. 225
40 -28.6001ztc_A mol:protein length:221 hypothetical protein TM0894  ali model follow..  12  29...............................................STVVYLEHKDRRIIIDPGNLSS-MDELEEKFSELGISPITDVLFTHVHLDHIFNSVLFENATFYVHEVYKTKNYLSFGGRIYSKVISSWKNVVLLKGEESLFDEKVKVFHT-PWHAREHLSFLLDTENVLITGDITPNRL-----SYYDIIKGYGSVQVKNFLDRVGRIDLLVFPHDAP................. 208
41 -28.1004v0h_A mol:protein length:266 METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROT  ali model follow..  14  21VVVLLQGYAEPEGVGDAVRADGSVTLVLPQTRGPASSHRESPRGSGGAEAALEEAARGPILVDTGGPWAR-EALLGALAGVAPGDVTLVVGTHGHSDHIGNLGLFPGAALLVSHDFCLPGGRYLPHGLGEGQPLRLGP-------------GLEVWAT-PGHGGQRDVSVVVAGTVVVAGDVFERDGDEDSWQALSEDPAAQERSRKRVLVV---ADVVVPGHGPP................. 234
42 -26.7004ad9_A mol:protein length:289 BETA-LACTAMASE-LIKE PROTEIN 2  ali model follow..  17  8......................RVERLSNRVVRVLG-CNPGPMTLQGTNTYLVGTGPRRILIDTGEIPEYISCLKQALTE-FNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYT-PGHTDDHMALLLEEENAIFSGDCILGEGTTVF-----EDLYDYMNSLKELLKI--KADIIYPGHGPV-----IHNAEAKIQQY. 214
43 -26.0002xf4_A mol:protein length:210 HYDROXYACYLGLUTATHIONE HYDROLASE  ali model follow..  11  11.............................................FSQNCSLIWCEQLAALVDPGGD---AEKIKQEVDAS-GVTLMQILLTHGHLDHVGAASELAQHGVPVIGPEKEDEFWLQGLPAQSRECQPLTPDRWLNDGDRVSVGNVTLVLHCPGHTPGHVVFFDEQSQLLISGDVIFKGGVGRS-DFPRGDHTQLIDAIKRKLLPLGDDVTFIPGHGPLSTLGYERLHNPFLQ... 209
44 -25.5002r2d_A mol:protein length:276 Zn-dependent hydrolases  ali model follow..  11  41.............................................IPVSAYLIQCTDATVLYDTGCHPESECNLPERLRQLGLSPISTVVLSHLHNDHAGCVEYFGKSRLIAHEDEFATAVRYFATGDHSSPYIVKDIEAWLATPRNWDLPGVNLLNFGTGHASGMLGLAVRLEKFLLVSDACYTATNYGPPARRAGDTIGYDRTVSHIRQYAESRSLVLFGHDREQFASLIKSTDGFYE... 276
45 -25.1005i0p_A mol:protein length:366 Beta-lactamase domain protein  ali model follow..  14  23......................DTFEVAPGVRWLRMPLPFS-------NLWLL-GQAGWTIVDCGISSEAIRTHWEQIRHLDGLPVLRVLVTHCHPDHFGLANWLCEGNVRLWMTPAALDKLRSRRSYYSDLVPAVPPRYRLREGDAVKIGART-VVTGYGHSPEHCALHSEADGVLISGDMVLPRISTNVSVFDLEPLALYLESLGRYETM-APDTLVLPSHGKP--AQLRAHHDARLEEVR 297
46 -24.6003dha_A mol:protein length:254 N-Acyl Homoserine Lactone Hydrolase  ali model follow..  12  1.........GRISMTVKKLYFIPAGRCMLDHSSVNSALTPGKLLNLPVWCYLLETEEGPILVDTGMPESAVDRIVNILKRVGYEPLLYIISSHLHFDHAGGNGAFT--NTPIIVQRTEYEAALHREEYMKECILPHLNYKIIEGDYEV-VPGVQLLYT-PGHSPGHQSLFIETEQVLLTIDASYKENFEDEVPFAGFDPELALSSIKRLKEVVKKEKIIFFGH-DIEQEKSCRVFPEYI.... 254
47 -24.3002br6_A mol:protein length:252 AIIA-LIKE PROTEIN  ali model follow..  13  11.....................IPAGRCMLDHSSVNSALTPGKLLNLPVWCYLLETEEGPILVDTGMPESAVDRIVNILKRVGYEPLLYIISSHLHFDHAGGNGAFT--NTPIIVQRTEYEAALHREEYMKECILPHLNYKIIEGDYEV-VPGVQLLYT-PGHSPGHQSLFIKTEQVLLTIDASYKENFEDEVPFAGFDPELALSSIKRLKEVVKKEKIIFFGH-DIEQEKSCRVFPEYI.... 252
48 -24.0001qh3_A mol:protein length:260 PROTEIN (HYDROXYACYLGLUTATHIONE HYDROLASE)  ali model follow..  15  9.............................................LTDNYMYLVIDDEAAIVD----PVQPQKVVDAARKH-GVKLTTVLTTHHHWDHAGGNEKLVKLGLKVYGGDDRIGAL----------------THKITHLSTLQVGSLNVKCLAPCHTSGHICYFVSEPPAVFTGDTLFVAGC---GKFYEGTADEMCKALLEVLGRLPPDTRVYCGH---------EYTINNLK... 181
49 -23.9001xm8_A mol:protein length:254 glyoxalase II  ali model follow..  20  9.............................................LKDNYAYILHDEDVGVVDPS----EAEPIIDSLKRS-GRNLTYILNTHHHYDHTGGNLELKDRGAKVIGSAMDKDRIPGIDMALKDG-----------DKWMFAGHEVHVMDT-PGHTKGHISLYFPGSRAIFTGDTMFSLSC---GKLFEGTPKQMLASLQKITSL-PDDTSIYCGHEYTLSNSKFALSLE...... 183
50 -23.1004fek_A mol:protein length:262 Putative diflavin flavoprotein A 5  ali model follow..  12  2..............SDSKPRDVQVLPIATNTKVLRAEIEYALERGTTSNS-YVIEGDKTAIIDPPVESFMKIYLEALQQTVNLKKLDYVILGHFSPNRIPTFKALLELQITFVCSLPAAGDLRAAFPDDNLNI------LPMRGKETLDLGKLKFLPIPSPRWPAGLCTYDVQTQILYTDKIFKEDQRYYFNCLMAPHAIHVEAALEKISDL--QVRLYAVGHGPLVRTSLIALTQAYADWSK 251
51 -22.9003aj3_A mol:protein length:274 4-pyridoxolactonase  ali model follow..  15  2...................SDTKVYLLDGGSLVLDGYHVFWNRGRFPVYSILIEHAEGRFLIDTGYDYEKHQTIPGALGLLGLEPIDVVVNSHFHFDHCGGNKYFPHAKKICHRSEVPQACNPQPFEHLGYSDLSFSAEAAEARGATAQLRGVKLIST-PGHSIGHYSLLVEFPRILFTIDAAYTQKSTLCQAAFHIDPVAGVNSMRKVKKLAEDHGALMYSHDMDNFKTYRTGTQFY..... 267
52 -21.3004chl_A mol:protein length:238 PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL  ali model follow..  18  28......................................................ESREAVLIDP----ETAPRDAQLIKEL-GLRLLYAVNTHCHADHITGSGLLRSL--------------LPGCQSVISRLSGAQADLHIEDGDSIRFGRFALETRAPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTL-PGDCLIYPAHD................... 180
53 -21.3002p18_A mol:protein length:311 Glyoxalase II  ali model follow..  15  31.............................................LKDNFSYLINDHTLAAVDVNAD---YKPILTYIEEHLKQTFSTILSTHKHWDHSGGNAKLKAELEAMNSTVPVVVV--------GANDSIPAVTKPVREGDRVQVGDLSVEVIDPCHTRGHVLYKVQHPQALFTGDTMFIAG---IGAFFEGDEKDMCRAMEKVYHIHDKVTFIFPGH---------EYTSGFMT... 228
54 -20.6003esh_A mol:protein length:280 Protein similar to metal-dependent hydrolase  ali model follow..  27..........................VPKPLWSKQYNANERNQINLPTHPILIQTAQYNLIIDAGIGNGKESHIIADLANLTPKDIDYVLMTHMHFDHAAGLTDQAGHNAIHVVQQDEWHEFIAPNIRS-KSTYWDKNKGDYSNKLILFEKHFEPMQHSGGHSFGHTIITIESDKAVHMGDIFPTTAHKNPLWVTAYDDYPMQSIREKIPYFIQQQYWFLFYHDENYFAVKYSDDGENIDAY. 270
55 -19.9004xuk_A mol:protein length:291 Putative hydrolase  ali model follow..  15  13....................DVQITALLDGTILKKYYADQEKGVQTSINAFLVNIGKSLILIDSGAASCFGSSVLSNLKASGYQPVDTILLTHLHPDHVCGISYVSNDEASFWLDPKQAAKLPKEKQANYLGTVEKIKQAIYQAKQRFKTYKLGDDIQGAGHTPGHFSYELKTESIVFIGDIVHSHTVPETAIEYDIDPKKAVETRLKQFANFAKNGQTIPGIGHTYSAD............. 278
56 -19.8002ohh_A mol:protein length:404 Type A flavoprotein fprA  ali model follow..  16  2....................KAAAKRISDGVY-WTGVLDWD--QGTTYNAYLVCGDEGVALIDNGTFDELMARVEDALQQVGMERVDYIIQNHVEKDHSGVLVELHRREAPIYCTEVAVKGLLKHYPSLREAEF-----MTVKTGDVLDLGGKTLTFLET-HWPDSMFTLLDEDGILFSNDALMDAARKFYANLITPLSKLVLKKFDEVKELLERIQMIAPSHGQI................. 236
57 -19.6004le6_A mol:protein length:324 Organophosphorus hydrolase  ali model follow..  14  24AAAPAQQKTQVPGYYRMALGDFEVTALYDGYLLARMFVASEKGVQTAVNAYLINTGDNLVLIDTGAAQCFGPVVQTNLKASGYQPVDTVLLTHLHPDHACGL-EVPQAEAEFWLDEATMAKAPEGMQGMFKMAQQAVAPYAKMNKLKPYKTEGELLVASPGHTPGHTSYLFKSQSLLVWGDILLNHAVPEVVFEFDVDSDQARQSRQRILAEAATDKLWVPGLGHV................. 303
58 -19.4004o98_A mol:protein length:337 organophosphorus hydrolase  ali model follow..  13  24AAAPAQQKTQVPGYYRMALGDFEVTALYDGYLLARMFVASEKGVQTAVNAYLINTGDNLVLIDTGAAQCFGPVVQTNLKASGYQPVDTVLLTHLHPDHACGL-EVPQAEAEFWLDEATMAKAPEGMQGMFKMARQAVAPYAKMNKLKPYKTEGELLVASSGHTPGHTSYLFKSQSLLVWGDILINHAVPEVVWEFDVDSDQARQSRQRILAEAATDKLWVPGLGHV................. 303
59 -19.4004ysb_A mol:protein length:233 Metallo-beta-lactamase family protein  ali model follow..  18  22......................................................ATRQAVLIDP----EQVDRDLQMVAEL-DLTLTHVFDTHVHADHITASGALRERQATVVGSVNGASCA----------------NVQVRHGDEVRVGQLVFQVL-PGHTDDSISYLLGDR--VFTGDALLVRGNGRTDFQNGNASQLYDSLTRVLFTL-PDETLVYPGHD................... 171
60 -19.0001e5d_A mol:protein length:402 RUBREDOXIN:OXYGEN OXIDOREDUCTASE  ali model follow..  10  1.....................MQATKIIDGFHDFHGYTLSPMGTTYNA---YLVEDEKTTLFDTVKAEYKGELLCGIASVIDPKKIDYLVIQHLELDHAGALPALIEAPEKIFTSSLGQKAMESHFHYKDWPV------QVVKHGETLSLGKRTVTFYET-HWPDSMVSWFADEKVLISNDIFGQNIAASERFSDQIPVHTLLKAIETLVGAGVAPEFICPDHGVI................. 229
61 -19.0002gcu_A mol:protein length:245 Putative hydroxyacylglutathione hydrolase 3  ali model follow..  19  27.......................................................DKPALLIDP----KTVDRDLKLIDEL-GLKLIYAMNTHVHADHVTGTGLLKTKGVKSVISKASGSKA----------------DLFLEPGDKVSIGDIYLEVRAPGHTAGCVTYVTPQPRMAFTGDAVLIRGCGRTDFQEGSSDQLYESVHSQIFTL-PKDTLIYPAHD................... 184
62 -18.8004d02_A mol:protein length:479 ANAEROBIC NITRIC OXIDE REDUCTASE FLAVORUBREDO  ali model follow..  12  3........................IVVKNNIH-WVGQRDWEKTLRGSSYNSYLIREEKNVLIDTVDHKFSREFVQNLRNEIDLADIDYIVINHAEEDHAGALTELMAQDTPIYCTANAIDSINGPEWNF----------NVVKTGDTLDIGNLIFVETPMLHWPDSMMTYLTGDAVLFSNDALFEQCQRYYANILTPFSRLVTPKITEILGFNLPVDMIATSHGVVWRDNPTQIVELYLKWAA 243
63 -18.8002q9u_A mol:protein length:414 A-type flavoprotein  ali model follow..  10  8.....................VQDQEMIPGVY-VRIFHGYHTDEGSSYNS-YFIDDECPTVIDSVKYPFAEEWLSRIAACCPLDKIKYVVMNHAEGDHASSLKDHYHKNATFVCTKKCQEHLKILYGMEKATW------LIVDDKYTLKIGKRTLKFIPV-HWPDSTFTYCPEDKILFSNDGFGQHYATSRRWADECDVSHVMKALEVASTV--EIKYILSAHGVSWRGDAMGLAIAEYDR.. 248
64 -18.7004zo2_A mol:protein length:294 Acylhomoserine lactonase  ali model follow..  16  60................................................NILLVKTKEKLILMDTGMGIERTGFLLKSLQKAGFSAITDIFLSHAHPDHIGGV-FISKIEHDFWINASIKDFNNSALKAHPERLNQIIPALQIQPKLKFYDLNKTLYQLAPGHTPGLTVTTISSEKLMYVADLIHSDVIPDWGFSGDTDLDIATASRKKFLKQLADTKARAPGLGFT................. 278
65 -18.5001p9e_A mol:protein length:331 Methyl Parathion Hydrolase  ali model follow..  16  54....................DFEITALSDGTQSALAKSFQKAPLETSVTGYLVNTGSKLVLVDTGAAGLFGPRLAANLKAAGYQPVDEIYITHMHPDHVGGLDFWLSQTNLDKAPDDESKGFFKGAMASLNPYVKAGKFKPFSGNTDLVPGIKALASHG--HTPGHTTYVVESQKLALLGDLILVAAVPSVTTQLDSDSKSVAVERKKAFADAAKGGYLIPGIGHI................. 311
66 -18.5001ycf_A mol:protein length:398 Nitric oxide reductase  ali model follow..  10  2......................QPVAITDGIYIRYFHGPAFSTHRGTTYNAYLIVDDKTALVDTVYEPFKEELIAKLKQIKDPVKLDYLVVNHTESDHAGAFPAIMELDAHVLCTQRAFDSLKAHYSHIDFNY------TIVKTGTSVSLGKRSLTFIEA-HWPDSMFTYVPEEALLLPNDAIMDEAAKYYANILMPFSNLITKKLDEIQKINLAIKTIAPSHGIIWRKDPGRIIEAYARWAE 247
67 -17.7003r2u_A mol:protein length:466 Metallo-beta-lactamase family protein  ali model follow..  15  30...............................................SQASYLIGCQKAMIID----PIRDLSSYIRVADEEGLTITHAAETHIHADFASGIRDVAIKNANIY--------VSGESDDTLGYKNMPNHTHFVQHNDDIYVGNIKLKVL-PGHTPESISFLLTDEGGLFSGDFIFVGKAVKVEGSSEIGAKQMFKSIESIKDL-PDYIQIWPGHGSPCGKSLGAIPTSTLGYEK 235
68 -17.5003tp9_A mol:protein length:474 BETA-LACTAMASE and RHODANESE DOMAIN PROTEIN  ali model follow..  13  15...............................................AHASYLVGCQEACVID----PARDVEPYLLTAKREGLRIVAALETHIHADFVSGAREMADRGAAICVSD-------EGPPEWKSEYVKAYPHRLLKDGDELHFGNVRIVVM-PGHTPEHVSYLLYDGKALFSGDFVFVGRVAGESGSSEALARQMFRSLRKFEAL-PDHVQVLPAHGSACGKALGAVPSSTVGYEK 221
69 -17.2001vme_A mol:protein length:410 Flavoprotein  ali model follow..  12  12.....................TERIFDDPEIYIRYFEAVWEIPEGISYNAYLVKLNGANVLIDGWKGNYAKEFIDALSKIVDPKEITHIIVNHTEPDHSGSLPATLKTDVEIIASNFGKRLLEG---------YGIKDVTVVKDGEEREIGGKKFKFVMT-HWPDTMVTYL--DGILFSCDVGGYLLPEILDDSNESVVERYLEGAEKLSSL--KIKALLPGHGLIWKKDPQRLLNHYVSVAK 254
70 -15.8004nur_A mol:protein length:633 PSdsA  ali model follow..  12  89.......................LFEVTDGIYQVRNYD--------LSNMTIVEGKDGITIFDPLISQETAKAALDLYYKHRKKPVVAVIYTHSHVDHYGGVRGVVDEAVKIYAPLGFLEHAVAENTTSAGTVTLIPPTDIIKETHVIDGLTYEFMYAPGSEAPAEMLYYIKEKKALNAAEDSTHTNTYSLRGAKIRDPLAWSKYLNEALKLWGDDVQVMPVWGNKEVREQLSLQRDMYRYIN 351
71 -15.7002cfu_A mol:protein length:658 SDSA1  ali model follow..  13  107.......................LFEVAEGIYQVRGFD--------LANITFIRGDSGWIVVDTLTTPATARAAYELVSRELERPIRTVIYSHAHADHFGGVRGLVEPQVQIIAPAGFMEAAIKENGLARGPLSLLAPTRLIEEDLVLDGVPFTFQNTPGTESPAEMNIWLPRQKALLMAENVVGTNLYTLRGAEVRDALGWSKYINQALHRFGRQAEVMPRWGNAEIVEVLEKQRDLYGYLH 369
72 -15.6004pdx_A mol:protein length:640 Putative alkyl/aryl-sulfatase YjcS  ali model follow..  12  89.......................LFKVTDKMYQVRGQD--------ISNITFVEGEKGIIVIDPLVTPPAAKAALDLYFQHRQKPIVAVIYTHSHTDHYGGVKGIISEAVQVIAPAGFMDEAISENTLATGDPSIIAPTKTIVEKMIIDGLEFDFLMTPGSEAPAEMHFYIPALKALCTAENATHTNFYTLRGAKTRDTSKWTEYLNETLDMWGNDAEVLPVWGNKHINDYIGKYRDTIKYIH 351
73 -15.3003kl7_A mol:protein length:235 Putative metal-dependent hydrolase  ali model follow..  14  29.............................................IKHGSLMLTYDNHSIQVDPVSEYADYTTF---------PKADIILITHEHGDHLDAIQAVEKSDTEIIANENSQKKLGKGKVLKNGDTDTSISYMKIEAVPAYNTTPGRDKYHPRHRDNG-YILTFDGLRVYIAGDTEDIPEMKDLKDINQPYTMTVSQAAKAARMFSP--KILYPYHYGDTKIGELKDALK...... 217
74 -15.3002yhe_A mol:protein length:668 SEC-ALKYL SULFATASE  ali model follow..  13  117.......................LFEVMPKLYQVRGLD--------PANMTIIEGDSGLVLIDTLTTAETARAALDLYFQHRKKPIVAVVYSHSHIDHFGGARGIIDEAVKVFAPSGFMEHAVSENTATNATNTLVAPNVLIEERHTVDGVELEFQLTLGSEAPSDMNIYLPQFKVLNTADNAPPANLLTPRGAEVRDAKAWAGYIDASLEKYGDRTDVLPVWGGDKVRTYLADQRDMYAFLN 380
75 -15.3002az4_A mol:protein length:429 hypothetical protein EF2904  ali model follow..  10  14.........................................GILTIGGTVIEVAYKDAHIFFDFGTETLINNRLVPELKDLYDPRLGYVFLSHAHLDHS-RMINYLDPAVPLYTLKETKMILNSLNRKPFEEKNFTREMIGLNKNDVIKVGEISVEIVPVDHDAYGLLIRTPDHFITYTGDLRLHGHNRE-------ETLAFCEKAKHTELLMMEGVSISFPEREPDPAQIAVVSEEDLVQ.. 242

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Alexey M. Eroshkin, Andrew LeBlanc, Dana Weekes, Kai Post, Zhanwen Li, Akhil Rajput, Sal T. Butera, Dennis R. Burton, Adam Godzik. bNAber: database of broadly neutralizing HIV antibodies. Nucl. Acids Res. 2013; published on November 7, 2013.

Jaroszewski L, Li W, Godzik A. In search for more accurate alignments in the twilight zone. Protein Sci. 2002 Jul;11(7):1702-13.